Synarel

Nafarelin is an intranasally administered synthetic form gonadotropin-releasing hormone used in the treatment of prostatic cancer, endomtriosis, and precocious puberty. It is used by some physicians off-label for infertility. In infertility, it initially causes an increase in production of LH and FSH before suppression.

Size Price Qty Add
1 X 8 ml Bottle
RRP: $1,451.65
You pay: $1,239.95 (Save 15%)

General Product Information About Synarel

Synarel Product Contains

Nafarelin (synthetic gonadotropin-releasing hormone, GnRH)

Synarel Product Indications

Nafarelin is an intranasally administered synthetic form gonadotropin-releasing hormone used in the treatment of prostatic cancer, endomtriosis, and precocious puberty. It is used by some physicians off-label fo infertility. In infertility, it initially causes an increase in production of LH and FSH before suppression.

Synarel Dosage and Administration

For inhibiting early LH surges in women undergoing in vitro fertilization or another type of assisted reproduction for the treatment of infertility.  NOTE:  This is an off-lable use, not approved by the FDA.

  • Optimal daily dose should be adjusted by fertility specialist.
  • Typically started during mid-luteal phase (day 21) for "long-protocol"
  • Typical dose: 200 mcg twice daily or 200 mcg three times daily intranasally; typically range is 400-800 mcg/day intranasally
  • Continue to use during oocyte stimulation with FSH followed by hCG administration to retrieve the eggs.
  • NOTE: Alternative dosing for "flare protocol" - not commonly seen.

Synarel Warnings, Side Effects and Potential Drug Interactions

  • Do not use topical nasal decongestants within 2 hours of nafarelin. Avoid sneezing during and immediately after the dose.
  • Nafarelin will cause an initial flare in testosterone or estrogen levels leading to bone pain, urinary problems including blood in the urine, and tingling in the feet and hands.
  • Do not administer in patients with undiagnosed abnormal vaginal bleeding.
  • Nafarelin is secreted in breast milk.
  • Common side effects: irregular menstruation, bone pain, sweating, dizziness, water retention, hot flashes, headache, nausea/vomiting, and pain at injection site.
  • Pregnancy Category X

Synarel Storage

Store the bottle upright at room temperature 25°C (77°F). Avoid storing at temperatures above 86°F (30°C).
Protect bottle from light.
Do not freeze.

Synarel Manufacturer

Pfizer Laboratory
Website: www.pfizer.com

Not approved by the FDA for infertility. Federal law prohibits dispensing without prescription.

Style Number: PFU-RSU-00001-CONFIG